BioPerine is a trademark formula that you often see in various supplements today. And you are probably wondering what it is and how it affects your health right?
Well, if you are intrigued about this ingredient and want to know more on how it provides any difference for your supplement, then this short article is for you.
Read on and learn how BioPerine works, its potential health benefits, and possible side effects.
What is BioPerine?
BioPerine is a specially researched formula, pioneered by Sabinsa Corporation (1), a US-based manufacturer and supplier of herbal extracts, cosmeceuticals, minerals and specialty fine chemicals.
This company has brought to market more than 100 botanical extracts and funded several clinical studies (most of which are partnered with other health institutions) in support of these privately researched products. They own more than 260 patents worldwide including BioPerine.
So What’s Behind BioPerine?
This simple formula is entirely based on one herb extract – black pepper.
Researchers from Sabinsa Corporation believes that the many health benefits of black pepper lies on its single active key chemical – piperine.
Piperine is a key compound that is found in both black and white pepper, which are known for their spice or hot taste. People use these herbs as food additives and flavorings.
Some of its known benefits include treatment of skin diseases, liver issues, bronchitis, nerve pain, cancer, stomach disorders and many others.
BioPerine is a patented formula sourced from black pepper fruits (piper nigrum), which is standardized to 95% piperine. As such, this patented formula has been used for over 20 years as a bioavailability enhancer.
And according to Sabinsa Corporation, this formula has shown to enhance absorption of nutrients by at least 30%.
This is also the reason why various supplements today use BioPerine such as Burn XT, Testogen and Sutolex.
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What are the Health Benefits of BioPerine?
Since this is a special supplement, expect BioPerine to provide similar (if not more) health benefits with black pepper extract. And of course, this patented chemical has been proven effective for various health benefits through these years.
Here are some of the notable health benefits of BioPerine that you should take note of.
Anti-Obesity Properties
Piperine, a key compound in BioPerine, has been shown to provide some measures of weight loss according to studies.
Based on this research test (2), piperine demonstrated beneficial metabolism during exercise by regulating carbohydrate and fat metabolism, including redox signals. This means that piperine can be used as a performance enhancing supplement.
Also, piperine has been found also to provide positive effects on weight loss if combined with curcumin (3), which is one of the herbs tested for BioPerine’s slimming efficacy.
According to this study (4), a combination of curcumin and piperine helped metabolic syndrome patients to significantly reduce their BMI, weight, and leptin, while providing significant increase in adiponectin (a hormone that plays a role in regulating glucose levels).
Anti-Diabetic Activity
BioPerine has been shown to lower blood sugar levels in various laboratory tests. This is the reason why this supplement is sometimes marketed for diabetics and people with related blood sugar disorders.
According to this study (5), piperine promotes glucose uptake, improves blood sugar metabolism and prevents hyperglycemia.
Additional 2012 study (6) suggests that piperine also significantly improved insulin sensitivity of 86 obese subjects.
Elevates Brain Performance
There have been dozens of clinical trials suggesting piperine’s ability to improve brain function in animals.
According to this rat study (7), piperine extract has a big role in preventing the onset of Alzheimer’s disease symptoms and other degenerative mental health disorders.
Piperine also showed potential benefits for symptoms of Parkinson’s disease (8).
Anti-Inflammatory Effects
Suffering from inflammation such arthritis and osteoarthritis? If yes, then BioPerine can help!
According to this animal study (9), piperine provided anti-inflammatory, antinociceptive, and antiarthritic effects in rat subjects. Other studies suggest similar results in mice and other animals.
Though this isn’t proven for human health, you may still expect some measures of anti-inflammatory effects with BioPerine.
Anti-Cancer Properties
Chronic diseases such as cancers are one of the major cause of deaths worldwide. Cancer is caused by development of mutated, abnormal cells due to excessive cell oxidation.
One way to combat this is to live a healthy and physically active lifestyle that can strengthen your immune system. So better immunity means less chances of developing cancer.
According to this study (10), piperine effectively slowed the reaction time of lymphocytes (cancer cells) which means black pepper’s cell inhibition effects.
This study (11) also showed that piperine’s supplementation triggered anti-inflammatory effects, which was associated with the lowering cancer cases in India.
Lowers Cholesterol Levels
High cholesterol levels is one major cause of heart-related diseases as it degrade the functions of arteries. So it is important to cleanse the arteries for better cardiovascular health.
Several animal lab tests showed positive results with regards to black pepper’s cholesterol-lowering effects (12).
And experts suggests that black pepper’s ability to absorb dietary supplements have similar cholesterol-lowering potential (13).
Why Supplement Manufacturers Use BioPerine?
So what is the reason behind supplement manufacturers use of BioPerine? Aside from the aforementioned health benefits, there is one major health effect that can truly benefit any supplement in the market – Nutrient Absorption!
Yes, nutrient absorption is the most important role of BioPerine in dietary supplements as it helps enhance the effects of other ingredients such as curcumin (14), resveratrol, caffeine, B vitamins, iron, carotene and many others.
Sabinsa Corporation refers to this effect as “Bioenhancement“, the ability to get more out of other nutrients that you consume. Interesting right?
So when you consume other agents together with BioPerine, you can assimilate much more of these ingredients. The result is increased efficacy and reliability of the supplement.
Does BioPerine Have Side Effects?
Since black pepper is an alkaloid like capsicum, piperine in BioPerine has been shown to help relieve nausea, headaches (15) and also aids in digestion (16).
What does this mean? It means that BioPerine or black pepper in general is generally safe for human consumption in averaged amounts used in foods.
Of course, like any herbal agents in the world, excessive consumption leads to side effects particularly burning sensations (17) in the throat and stomach.
Also, since we all know that BioPerine can increase the absorption of some supplements or ingredients, doctors and health experts are reminding people that high absorption of such drugs can lead to dangerous health circumstances.
I suggest you consult your doctor first before you take any products that contain BioPerine.
Conclusion
There you have it! Now you know what BioPerine is and how it affects your health.
Basically when taking this chemical from Sabinsa Corporation, you also getting all beneficial effects of black pepper’s active compound piperine. It is like an upgraded black pepper supplement.
But the common reason among health companies about their use of BioPerine, is its ability to effectively absorb other nutrients contained in their supplements.
This what makes their brands more effective and reliable, while lessening any chances of adverse effects.
Interested? If you are intrigued by the power of BioPerine, then check out your supplement right now! You never know it might contain this amazing agent.
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References:
BioPerine
by: Sabinsa Corporation
https://bioperine.com/index.php/aboutbioperine
Piperine Enhances Carbohydrate/Fat Metabolisn Skeleteal Muscle During Acute Exercise in Mice
by: Jisu Kim, Kang-Pa Lee, Dae-Won Lee, and Kiwon Lim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496355/
Curcumin
by: Sabinsa Corporation
https://bioperine.com/index.php/curcumin
The Effects of Curcumin on Weight Loss among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by: Maryam Akbari, Kamran B Lankarani, Reza Tabrizi, Majid Ghayour-Mobarhan, Payam Peymani, Gordon Ferns, Amir Ghaderi and Zatollah Asemi
https://www.frontiersin.org/articles/10.3389/fphar.2019.00649/full
Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle
by: Ayumi Maeda, Takeshi Shirao, Daishi Shirasaya, Yasukiyo Toshioka, Toko Tamashita, Mitsugu Akagawa, and Hitoshi Ashida
https://pubmed.ncbi.nlm.nih.gov/29683271/
Improvement in Insulin Resistance and Favourable Changes in Plasma Inflammatory Adipkines After Weight Loss Associated with Two Months Consumption of a Combination of Bioactive Food Ingredients in Overweight Subjects
by: Mariangela Rondanelli, Annalisa Opizzi, Simone Perna, milena Faliva, Sebastiano Bruno Solerte, Marisa Fioravanti, Catherine Klersy, Edda Cava, Maddalena Paolini, Luciano Scavone, Paola Ceccarelli, Emanuela Castellaneta, Claudia Savina, and Lorenzo Maria Donini
https://pubmed.ncbi.nlm.nih.gov/23271695/
Methanolic Extract of Piper Nigrum Fruits Improves Memory Impairment by Decreasing Brain Oxidative Stress in Amyloid Beta (1-42) Rat Model of Alzheimer’s Disease
by: Lucian Hritcu, Jaures A Noumedem, Oana Cioanca, Monica Hancianu, Victor Kuerte, Marius Mihasan
https://pubmed.ncbi.nlm.nih.gov/24442916/
Neuroprotective Effects of Piperine on the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson’s Disease Mouse Model
by: Wei Yang, Yu-Hua Chen, Hao Liu, and Hong-Dang Qu
https://pubmed.ncbi.nlm.nih.gov/26648012/
Anti-Inflammatory and Antiarthritic Effects of Piperine in Human Interleukin 1Beta-Stimulated Fibroblast-Like Synoviocytes and in Rat Arthritis Models
by: Jun Soo Bang, Da Hee Oh, Hyun Mi Choi, Bong-Jun Sur, Sung-Jig Lim, Jung Yeon Kim, Hyung-In Yang, Myung Chul Yoo, Dae-Hyun Hahm, and Kyoung Soo Kim
https://pubmed.ncbi.nlm.nih.gov/19327174/
Inhibition of Lipopolysaccharide-Induced Inflammatory Responses by Piperine
by: Gi-Sang Bae, Min-Sun Kim, Won-Seok Jung, Sang-Wan Seo, Seung-Won Yun, Sung Gyu Kim, Rae-Kil Park, Eun-Cheol Kim, Ho-Joon Song, and Sung-Joo Park
https://www.sciencedirect.com/science/article/abs/pii/S0014299910004760
Chronic Diseases, Inflammation, and Spices: How are they Linked?
by: Ajaikumar B Kunnumakkara, Bethsebie L Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti, and Bharat B Aggarwal
https://pubmed.ncbi.nlm.nih.gov/29370858/
Black Pepper and Piperine Reduce Cholesterol Uptake and Enhance Translocation of Cholesterol Transporter Proteins
by: Acharaporn Duangjai, Kornkanok Ingkaninan, Sakonwun Praputbut, and Nanteetip Limpeanchob
https://pubmed.ncbi.nlm.nih.gov/22736065/
Efficacy and Safety of Turmeric and Curcumin in Lowering Blood Lipid Levels in Patients with Cardiovascular Risk Factors: A Meta-Analysis of Randomized Controlled Trials
by: Si Qin, Kufan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Hong Ren, and Huaidong Hu
https://pubmed.ncbi.nlm.nih.gov/29020971/
Influence of Piperine on the Pharmackinetics of Curcumin in Animals and human Volunteers
by: G Shoba, D Joy T Joseph, M Majeed, R Rajendran, and P S Srinivas
https://pubmed.ncbi.nlm.nih.gov/9619120/
Piperine and its Role in Chronic Diseases
by: Giuseppe Derosa, Pamela Maffioli, and Amirhossein Sahebkar
https://pubmed.ncbi.nlm.nih.gov/27671817/
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
by: K Srinivasan
https://pubmed.ncbi.nlm.nih.gov/17987447/
Effects of Piperine, the Pungent Component of Black Pepper, at the human Vanilloid Receptor
Fergal N Mcnamara, Andrew Randall, and Martin J Gunthorpe
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576058/
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