Phentermine is one of the most popular (if not the most popular) weight loss prescription drug in the market today, and it comes in many brands.
Primarily an appetite suppressant aid, this drug has helped thousands or even millions of people lose weight fast by either curbing their appetite or having a complete control over their cravings.
Yes, Phentermine may also be used as a fat burner or metabolism booster, but it is designed as a potent appetite suppressing formula. So if you have issues with your excessive desire to eat, then you might want to consider talking to your doctor about this option.
One of the reasons why this drug is so powerful is its ability to influence your brain. Can it truly affect your brain or it’s just you expecting to easily not getting starved? Does this drug negatively affect your cognitive function?
All these will be discussed in this detailed article about Phentermine’s effect to your brain.
What is Phentermine?
As mentioned above, Phentermine is a prescription drug that helps people lose weight by helping them to control their food cravings and appetite, in short it is an appetite suppressant.
It works by stimulating your central nervous system and works similarly like Amphetamine. So you see, this drug affects your brain to produce effects.
Because of the popularity and effectiveness of this drug, many people have thought that using this drug can help them reduce weight fast. But that is not the case!
This drug is not a weight loss miracle and you should still follow a healthy diet if you want to successfully lose weight. So avoid those Phentermine weight loss myths that you often see on the Internet!
You may read my in-depth review of Phentermine here to learn more.
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So How Does Phentermine Affect the Brain?
Now that you know that this drug is an appetite suppressant and works as a brain stimulant, how does it really work that it can influence the brain?
First off, there are no definitive study why Phentermine triggers appetite reducing effects but one thing is certain – we already know its primarily role!
Taking this drug helps increase neurotransmitter levels in your brain (1).
Neurotransmitters are chemical messengers that reside inside the body and plays a big role on your appetite. When your levels of neurotransmitters increases, you feel less hungry for a period of time.
Some of the known neurotransmitters include dopamine, serotonin and norepinephrine, which are of course commonly mentioned in most weight loss conversations.
A study (2) about brain regulation of appetite and satiety shows that these neurotransmitters are indeed have a big role in reducing food cravings that promotes weight loss.
With that said, increasing your levels of neurotransmitters isn’t just beneficial for losing weight, but it can also aid a whole lot more health issues.
For example, Phentermine can help reduce symptoms of binge eating disorders (BED) and bulimia nervosa. Both health problems deals with excessive eating of large amounts of food that sometimes lead to physical discomfort and feelings of guilt or shame.
A 12-week study (3) that involves both obese and overweight individuals with BED, have shown significant reductions in weight, BMI and binge-eating episode by taking a combination of Phentermine and Topiramate.
So yeah, Phentermine is quite useful in influencing your brain in lowering cravings and suppressing your appetite, which leads to either modest weight loss or significant body weight reduction.
What are the Known Bad Effects of Phentermine to the Brain?
You probably know that prescription drugs such as Phentermine isn’t a perfect aid for weight loss as this drug is also infamous for its side effects.
Some of the notable adverse effects of this drug include dry mouth, nausea, vomiting, diarrhea, constipation, increases blood pressure levels, lung problems, heart issues, irritability, seizure, vision changes, weakness, affects blood sugar levels, chest pain, shortness of breath and many others.
There are even reports of this drug’s negative effects on preconception weight loss and pregnancy outcomes (4). There is also a wide debates whether this drug is also harmful for fertility and reproductive health for both men and women.
Of course, we shouldn’t take away the fact that this drug can also interact with other medicines so if you are taking medications for a particular health issue, then you need to talk to your doctor first before taking Phentermine.
There are also some reports of death by taking this drug, so rest assured that you are increasing your risk of death or serious health side effects when taking this drug.
Now what are the negative effects of this drug to your brain? Aside from positively affecting your levels of neurotransmitters, Phentermine can alter your sleeping patterns or can even trigger insomnia. But this is just the mild part.
According to this report (5), a single case of a female patient Phentermine user was documented for having repeated cases of psychotic episodes. The symptoms resolved after she stopped taking the drug, then relapsed when she started taking the drug again.
There is no concrete study suggesting that Phentermine can really cause psychosis to female or male patients. However, this case could help you decide whether you want to still try this drug or not for weight loss.
Another terrifying effect of this drug to the brain is the increased probability brain stroke.
According to this study (6), there is a big chance that taking Phentermine can possibly increase your risk for ischemic stroke due to Amphetamine’s vasoconstrictive properties which has been associated with ischemic stroke.
As mentioned above, both Phentermine and Amphetamine though different drugs, both works the same way.
The Bottom Line
Now you know that facts about Phentermine’s effects to the brain. Would you still like to try this prescription drug’s for weight loss? Or, you finally realized that the negative effects highly outweighs the potential benefits? I hope you’ll choose the latter part.
Yes, this drug is one of the best in the market but it is also the worse with regards to developing side effects. I know that you are smart enough to choose which is the best for your health.
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References:
Pharmcotherapy of Obesity: Available Medications and Drugs Under Investigation
by: Eleni Pilitsi, Olivia M Farr, Stergios A Polyzos, Nilolaos Perakakis, Eric Nolen-Doerr, Aimilia-Eirini Papathanasiou, and Christos S Mantzoros
https://pubmed.ncbi.nlm.nih.gov/30391259/
Brain Regulation of Appetite and Satiety
by: Rexford S Ahima, and Daniel A Antwi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710609/
Combination Phentermine-Topiramate Extended Release for the Treatment of Binge Eating DisordeR: An Open-Label, Prospective Study
by: Anna I Guerdjikova, Stephanie Williams, Thomas J Blom, Nicole Mori, and Susan L McElroy
https://pubmed.ncbi.nlm.nih.gov/30013815/
A Retrospective Study Examining Phentermine on Preconception Weight loss and Pregnancy Outcomes
by: Julia J Change, Ruth B Lathi, and Sun H Kim
https://pubmed.ncbi.nlm.nih.gov/32407664/
Recurrent Psychosis After Phentermine Administration in a Young Female: A Case Report
by: Hyun-Sic Jo, Sheng-Min Wang, and Jung Jin Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361044/
Weight Loss or Brain Loss?: Long Term Use of Phentermine Possibly Increases Risk for Ischemic Stroke
by: Cherry Onaiwu, Luay Sarsam, and Carrie Valenta
https://shmabstracts.org/abstract/weight-loss-or-brain-loss-long-term-use-of-phentermine-possibly-increases-risk-for-ischemic-stroke/
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